Guikan, who has appeared sparingly for the Kenyan champions since his move from Madagascar last January, will come in place of Meddie Kagere, who will be ineligible for the Wednesday action.
"With the absence of Meddie, we have to change our system of play to make Jacques Tuyisenge and Guikan be comfortable with each other on the pitch,” Kerr revealed during a pre-match interview.
“l believe in my players...they badly need this and we badly need it as well and the same applies to all fans in Kenya. We are going for a win. We hope to get the necessary support."
The pair played together on Sunday in a friendly against Hull City but they could not click. Guikan, in particular, was very wasteful in the first half before he was substituted for Kagere.
Kerr said playing at home will add more pressure on his players but he remains hopeful that his charges will follow the rule book when they step onto the pitch at Kasarani stadium.
"We have pressure both on and off the pitch but we keep working hard on the progress we have made so far. l always talk to my players and technical bench members and a big credit to my players they are following instructions."