Nuno Espirito Santo's side have been in fantastic form in front of goal in recent weeks, hitting an impressive 15 goals in their last five fixtures.
Wolves, then, will be determined to maintain their scoring streak when Rafa Benitez's Magpies visit Molineux.
Santo's side are strong favourites to pick up all three points. Indeed, a home win chalked up as a 4/6 (1.67) chance with William Hill.
Newcastle are available at 5/1 (6.0) to alleviate their fears of relegation with a vital victory whilst William Hill go 13/5 (3.60) that these two teams are forced to settle for a share of the spoils.
Wolves have a fully-fit squad from which to choose. Raul Jimenez, who has scored six goals in his last nine matches, is expected to lead the line for the hosts.
On-loan West Brom striker, Salomon Rondon, will lead the Newcastle attack and club record signing, Miguel Almiron, is poised to make his debut for the Magpies.
Newcastle have won just two of their 14 away matches inside 90 minutes this season.
Furthermore, the Magpies have scored more than one goal in just two of their last 15 Premier League matches on their travels and it is 19/20 (1.95) that Benitez's men draw a blank when they visit Molineux.
There is, however, reason for hope for Newcastle.
Wolves have managed just one clean sheet in their last 11 matches and recently conceded four goals in 180 minutes against League One strugglers, Shrewsbury Town.
Wolves have often struggled for solidity in defence this season but Santo's side pack a powerful punch but on the front foot - as underlined by their recent goalscoring prowess.
William Hill's 7/4 (2.75) quote, therefore, for the hosts to win a match featuring at least three goals could represent outstanding value.
The selection would have landed in each of Wolves' last six victories in all competitions.