Three consecutive victories have fired the Gunners up to fourth and they’ll be hoping to continue their fine run against a side who have failed to beat them in four of their last five league visits to the Emirates.
Arsenal have also won their last four Saturday evening kick-offs at home, though their last defeat arrived at the hands of United in November 2014.
Former Red Devil Danny Welbeck is pushing for a start and Wenger might be tempted to use the England international, who has scored in each of his last three appearances against his former side in all competitions.
Second-place United will be desperate to take all three points to keep runaway leaders Man City in sight.
Sitting pretty with 40 points on the board already, only Tottenham in 1960-61 can match City’s start to this top-flight season after 14 games (W13 D1)
Third-placed Chelsea, meanwhile, welcome back former manager Rafa Benitez hoping to extend their run of 15 wins in 22 PL games against Newcastle at Stamford Bridge.
The Egyptian has now has had a hand in 14 goals in his 14 PL games for Liverpool (12 goals, 2 assists).
Tottenham, down in sixth, head to Watford hoping to avoid a fourth consecutive away defeat. They last lost four in a row on the road in January 2009 under Harry Redknapp.
Who will handle the pressure?