Spurs are stuttering in their quest for Champions League football, which the club must secure to smoothen the transition into a new stadium.
The Saints have won just four times this season and their current run of results is ramping up the pressure on head coach Mauricio Pellegrino.
Unsurprisingly, the hosts are firm favourites at 2/5 (1.40) to gain their 11th league win of the campaign.
Only four teams have drawn more home games than Tottenham though, who have already dropped nine points at Wembley, five more than at White Hart Lane in the entirety of last season.
Kane to break another record?
Charlie Austin has scored five of Southampton’s last nine goals but looks set for a spell on the sidelines due to an injury sustained in Saints' 1-1 draw against Huddersfield and is likely to blunt the visitors' attack even further. The striker has also been charged with violent conduct following an incident in that match.
Harry Kane meanwhile scored a hat-trick in the 3-0 win at Burnley last time out and is 7/1 (8.0) for his eighth treble of 2017. The England international is just 1/2 (1.50) to find the net anytime and break set a new Premier League record for the number of goals in a calendar year, his treble at Turf Moor took him level with Alan Shearer's record of 36.
Saints to keep it tight?
Southampton have avoided defeat by a margin of more than one goal against both Manchester clubs, Arsenal and Chelsea so far this season and are available at 5/6 (1.83) with a +2 handicap. Their hosts have failed to win by two or more in six of their nine home games and have won just one of their five Premier League matches that have come within three days of the previous fixture.
Tips and Predictions
62% of Southampton's away matches have seen under 2.5 goals, as have 67% of Tottenham’s clashes at Wembley and a repeat is 21/20 (2.05), which comprises our best bet.