Mauricio Pellegrino's men enjoyed a thrilling 3-2 win against West Bromwich Albion last weekend and the Saints are bidding for back-to-back Premier League victories for the first time since April.
The enormity of the task facing the hosts, however, is reflected in dabblebet's 7/2 (4.50) quote for the Saints to secure all three points.
Liverpool have won six of their last eight Premier League away matches and Jurgen Klopp's charges are chalked up as a 4/5 (1.80) chance here.
Southampton have drawn three of their last four matches in this competition and dabblebet offer 14/5 (3.80) that the score remains level at the end of 90 minutes in Hampshire.
Southampton's James Ward-Prowse has scored four goals in his last six matches and could be a key man here.
Klopp could name the same starting line-up that played out a thrilling 2-2 draw with Tottenham Hotspur last weekend.
Goals at both ends?
Southampton have scored in nine of their last 10 matches in all competitions, while there have been goals at both ends in each of their last five Premier League fixtures.
Liverpool have scored at least three goals in all but one of their last eight away wins, and dabblebet go 2/1 (3.0) that the men from Merseyside manage more than two goals at St Mary's.
Tips and predictions
There is plenty of potential for goals in this game and the Reds may prove too hot to handle for the hosts on this occasion.
As such, dabblebet's 6/4 (2.50) quote for Klopp's side to take all three points from a match featuring at least three goals could well prove popular with punters.
The 6/4 (2.50) selection would have landed in each of the Reds' nine wins away from home in all competitions thus far this term.