Athletic, for their part, need a point to wrap up seventh spot and a place in the Europa League qualifiers, although a win for the Basques would see them leapfrog Sevilla into sixth and avoid having to contest the qualifying rounds.
Only Barcelona, Real Madrid and Atletico Madrid have won more home matches than Sevilla this season. The Andalusians are offered at 4/5 (1.80) with bet365 to record their 12th league victory of the season in front of their own fans.
Watch and bet live on Sevilla vs Athletic Club
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Sevilla are without Andre Silva, Daniel Carrico, Max Wober and Maxime Gonalons who are all injured while Ever Banega remains suspended. However defender Simon Kjaer who had to go off at half-time last weekend should be available.
Athletic have no major injury concerns.
Athletic are unbeaten at home since October yet the Basques have won just four of their last 21 away games, and their total of 15 goals scored on the road this term is the second-lowest in the division.
In seven of their 18 away clashes this term, Gaizka Garitano's side have failed to find the back of the net, and in their last three matches away to sides above them (Real Madrid, Getafe and Valencia) Athletic have drawn a blank.
Sevilla are not necessarily the most robust defensive unit, yet they have managed seven home clean sheets this season and could well be able to keep out a goal-shy Athletic attack.
Tips and predictions
Sevilla are priced at a healthy looking 7/4 (2.75) to keep a clean sheet, and their opponents have failed to score in four of their last six away games. Under 3.0 goals on the Asian goal line at 7/10 (1.70) could also be worth considering.
Odds correct at the time of writing. Please gamble responsibly.