Matias Almeyda’s men are unbeaten in six fixtures in front of their own fans, taking 16 points from the last available 18.
Having lost just once in six home games against this opposition, they are 21/20 (2.05) favourites with William Hill to come out on top yet again.
However, the Galaxy are nine points clear of their Californian rivals in second place in the Western Conference, and are priced at 9/4 (3.25) to extend the gap with a victory here.
The sides shared a 3-3 draw in their last meeting, and there are odds of 27/10 (3.70) available on them cancelling each other out once more.
Danny Hoesen, Shea Salinas, and Paul Marie are all injury doubts, while Anibal Godoy is definitely ruled out and Nick Lima and Harold Cummings are on international duty.
Jonathan dos Santos and Giancarlo Gonzalez are also with their countries at the Gold Cup, with Romain Alessandrini a long-term injury absentee as he continues his recovery from knee surgery.
Last year’s six-goal stalemate was just the latest in a run of high-scoring thrillers between this pair at this stadium, with the last four encounters in Northern California averaging four goals per game.
This trend looks likely to continue considering the Quakes have scored 20 goals in their last seven matches in their own back yard, while Guillermo Barros Schelotto’s team has not failed to find the net in five MLS away games.
All in all, odds of 13/10 (2.30) look like solid value on over 3.5 goals being scored for the fourth league meeting in five matches between San Jose Earthquakes and LA Galaxy at Stanford Stadium.