Los Rojiblancos have only finished above their more illustrious neighbours once in the last 22 years, yet heading into this weekend's game they hold a four point advantage over Zinedine Zidane's men.
Zinedine Zidane has never beaten Atletico Madrid at the Bernabeu in La Liga as manager, with Diego Simeone's side having won three and drawn one of their last four league visits.
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Given that both sides have European quarter finals in midweek, it remains to be seen how the managers approach the selection of their respective elevens.
Lucas Vazquez, Gareth Bale and Marco Asensio are likely to come into the starting eleven for the hosts, while Nacho Fernandez picked up an injury last weekend and will miss out for Real Madrid
Kevin Gameiro and Fernando Torres could feature for the visitors, but Filipe Luis is out of the rest of the season for Atletico.
Another cagey Madrid Derby
This will be the twelfth meeting between these two sides in the last three years, and recent La Liga derbies point to a close clash on Sunday.
Atleti boast the division's meanest defence and on their last four league visits to the Bernabeu, they have conceded just two goals.
Meanwhile, the first ever derby at the Wanda Metropolitano back in November ended goalless as the two sides managed just four shots on target between them.
Tips and predictions
Under 2.5 goals is priced at 19/20 (1.95) and has paid out in four of the last five derbies.
Furthermore, nine of Atletico's last 11 away league games have seen less than three goals and so there is every chance of another low-scoring game at the Bernabeu this weekend.