Real Madrid will be without midfielder Isco for a spell after the club confirmed he has suffered a hamstring strain.
The 27-year-old made his second appearance of the season as he started Saturday's 1-1 draw with Real Valladolid.
He was, however, forced off in the 68th minute due to injury and is now set for a spell on the sidelines with Madrid announcing on Wednesday that the Spaniard is struggling with a muscle problem.
A timescale has yet to be revealed although, depending on the severity of the problem, it could well be that the Spain international is out for as much as four weeks.
A statement on the club's official website read: "After the tests carried out today by the Real Madrid Medical Services, our player Isco has been diagnosed with a muscular injury in the right femoral biceps. His recovery will continue to be monitored."
The good news for Los Blancos is that Isco's injury has come shortly before the international break, giving him an extended period to recover.
He is, however, now the sixth Real player to pick up a muscle injury already this season with Ferland Mendy, Brahim Diaz, James Rodriguez and Rodrygo all suffering similar issues.
As a result, Zinedine Zidane faces selection issues with his squad looking so thin ahead of Sunday's visit of Villarreal.
Los Blancos kicked off their season with a 3-1 win over Celta Vigo, with goals from Karim Benzema, Toni Kroos and Lucas Vazquez securing the three points despite a second-half red card for Luka Modric.
They were, however, held by Valladolid in a shock result at the Bernabeu, with Benzema's 82nd-minute opener cancelled out by Sergi Guardiola.
After facing Villarreal on September 1, Madrid will then have a break 14 days before their next fixture against Levante, where Hazard could well make his competitive debut for the club.