Jurgen Klopp's side hold a two-point lead at the top of the table, albeit they have played a game more than Manchester City.
The holders beat Crystal Palace 3-1 earlier in the day and top bet365's Premier League winner odds at 8/11 (1.73) . The top two have gotten much closer together in the betting after the weekend's action though.
While both sides continue to target European success as well as domestic glory, it's the Reds that would appear to have the most straightforward top-flight run in.
While City still have the upper hand, back-to-back encounters with Tottenham and Manchester United looks a tough assignment. Guardiola's side finish the season with trips to Burnley and Brighton either side of Leicester's visit to the Etihad Stadium, which could be played in-between a Champions League semi-final if they qualify at Spurs' expense on Wednesday night.
The reigning champions are on a nine-match winning streak in the league though, plus they have a better goal difference than the Reds. That's a factor that could prove crucial with so little between the pair at this late stage.
Should both teams win their remaining games, the Premier League title will remain in Manchester. However, Liverpool will hope that their bitter rivals on the red half of the city can do them an unlikely favour at Old Trafford, especially if Spurs fail to dent the holders' challenge this weekend.
With Harry Kane unavailable for Mauricio Pochettino's men, City are just 3/10 (1.30) to pick up maximum points at the Etihad Stadium in Saturday's early kick-off. Spurs won the first leg of their Champions League encounter, but are huge outsiders for the second meeting in four days, available at 17/2 (9.50).
A draw would hand the advantage back to Klopp's side and can be backed at 17/4 (5.25) with bet365 at the time of writing.
Odds correct at the time of publish. Please gamble responsibly.