Both south coast clubs have taken four points from as many games in the top-flight and the bookmakers have the home side as 6/5 (2.20) favourites. The draw is 12/5 (3.40) and the visitors are available at 3/1 (4.0).
Southampton got a timely victory over Crystal Palace to kick-start their campaign before the international break and Mark Hughes will want his side to build on that display.
SportPesa have a new customer offer ahead of Monday evening's clash. Anyone opening a new account can take a boosted price of 3/1 (4.0) on Saints avoiding defeat. £15 max bet. Winnings paid in bonuses. Terms and conditions apply.
Usually this selection is just 3/10 (1.30) so the chance to get such a chunky quote about two of the three match result outcomes is an attractive one.
To take up this offer simply register through the links provided and back Southampton/Draw on the Double Chance market at the usual price. Then, if the home side take at least a point then your returns will be topped up to the value of a 3/1 (4.0) winner.
Brighton have proved tough opponents at the Amex since arriving in the top tier – as Manchester United learned a few weeks ago - but on the road their form has left a lot to be desired.
Chris Hughton led his side to just two wins away from home last season, losing 12 times. That travel sickness is reason enough to consider this selection as a worthy one.
St Mary's isn't the toughest test they'll face this term, but Southampton should be able to take something from the game.
The sides played out two 1-1 draws in the previous campaign and getting 3/1 (4.0) about the home win and draw looks a solid offer for those able to take advantage as a new SportPesa customer.Southampton/Draw (Double Chance) at 3/1 with SportPesa