Jurgen Klopp's men produced a dominant display in last week's quarter-final first-leg fixture at Anfield and hold a commanding 2-0 advantage ahead of Wednesday's return leg in Portugal.
It would, therefore, be a major upset should Sergio Conceicao's side turn this tie on its head.
Liverpool ran riot on Portuguese soil in this competition last term, enjoying a fantastic 5-0 win against Conceicao's men.
It is little surprise, then, that the Reds are SportPesa's 11/10 (2.10) favourites to win on Wednesday night. A draw, of course, would see Klopp's men safely through and SportPesa offer 12/5 (3.40) that this tie ends level.
Porto have won six of their last seven Champions League ties on home soil. The hosts are available at 53/20 (3.65) to come out on top against last season's runners-up.
Moussa Marega had scored in six successive Champions League ties before drawing a blank at Anfield. The 27-year-old striker will lead the line for the hosts and is surely pivotal to Porto's chances of mounting a famous fightback.
Liverpool have a seemingly comfortable advantage and remain in pursuit of a first Premier League title in 29 years, so Klopp will be keen to keep his key protagonists as fit as possible for the run-in and may rotate.
There have been goals at both ends in seven of Porto's nine Champions League ties so far this season. Furthermore, there have been at least three goals scored in eight of Liverpool's last 10 Champions League ties away from Anfield.
Conceicao's men will certainly need to adopt an aggressive approach as they seek to turn this tie around but will not be fazed by the enormity of the task in front of them.
The Portuguese champions have scored in each of their 24 competitive home fixtures so far this season and should the hosts score first, they will surely feel that they are capable of ending the Reds' European dreams.
Liverpool, too, carry a live threat and they will expect to have chances to wrap up the tie. The Reds have hit eight goals in their last three matches away from Anfield, including last month's magnificent 3-1 victory in Munich.
SportPesa's 5/4 (2.25) quote, therefore, for at least three goals to be scored - and both teams to score - could represent real value for punters.