The Germany international has been in good form for Pep Guardiola's side, who have won all but one of their competitive matches this season.
Sane has seven goals from 14 games in all competitions as he continues to link up well with the likes of Kevin De Bruyne and Sergio Aguero.
The left winger will come up against right-back Hysaj at the Stadio San Paolo in midweek, but the 23-year-old is sure he can contain the threat as Napoli look to recover from 2-1 defeat they suffered in the previous game in Manchester.
"He is a strong player, technically and physically strong and we will talk about him, but I have already studied how to stop him," the Albania international said.
Napoli came from behind to beat Genoa in midweek to ensure they stay top of Serie A after 10 games. Maurizio Sarri's side are touted as potential candidates for the title this season as they remain unbeaten and three points ahead of Juventus, an idea Hysaj gives fuel to.
"Nobody knows what will happen with the Scudetto, but we deserve it, both the team and the city," he said.
"We are very happy for the Wednesday's win because Genoa are a good team and it is always a hard field. We've been good at reacting and playing our own game. We've been very mentally strong when we're losing games, even in Manchester we reacted and eventually we could even tie."
Before taking on City, Napoli take on Sassuolo at home in the league, while City face West Bromwich Albion on Saturday.