Having provided Manchester City's most memorable Premier League moment with the late winner over QPR on the final day of the victorious 2011-12 season, Sergio Aguero could well set them up for another title at Old Trafford on Wednesday.
No player has scored more Manchester derby goals than Aguero's total of 11, while only Alan Shearer has scored more Premier League goals against Manchester United than the Argentina international.
On target in November's reverse encounter at the Etihad Stadium, he is William Hill's 16/5 (4.20) to break the deadlock in this crucial clash and looks a strong anytime bet at 10/11 (1.91) against a defence that has shipped seven goals in the last two matches.
Getty ImagesIn contrast, Raheem Sterling has never found the net in 15 appearances against the Red Devils, but is priced at even odds (2.00) to end that barren run after scoring 12 goals in his last 12 matches for club and country.
Meanwhile, Bernardo Silva represents a tempting longer shot at 5/2 (3.50) anytime odds after getting on target in four of his last six starts for Pep Guardiola's side.
After four games without a goal from open play, Ole Gunnar Solskjaer's team will be wondering where the inspiration will come from as they look to avoid humiliation at the hands of their local rivals.
Romelu Lukaku hasn't hit the back of the net in seven matches since firing twice against PSG last month, although he remains his side's 15/2 (8.50) favourite to open the scoring, and priced at a lengthy 9/4 (3.25) to merely strike anytime.
Without a goal in four fixtures, local star Marcus Rashford can be backed at 13/5 (3.60) to grab a third derby goal of his young career.
Considering his responsibilities as penalty taker, Paul Pogba may represent the best value bet for United at 13/5 (3.60) - having struck twice in his side's 3-2 win over City at the Etihad Stadium last season.
Aguero to score anytime at 10/11 (1.91) for a 2pt stake with William Hill
William Hill