Manchester United's Romelu Lukaku has netted five times in the competition this season and is enjoying a rich run of form, scoring ten goals in his last 12 games for club and country.
Harry Kane, meanwhile, has four FA Cup goals to his name this term, although the Spurs man has been slightly hampered with injuries in recent weeks and managed only two goals in his last eight appearances.
Despite a slight drop off in his scoring rate in the last few weeks, Kane is the shortest priced player to net with bet365 offering him at 10/11 (1.91) to score at anytime.
Eriksen to outshine Rashford
Of the last four goals that United have scored against Spurs, only one has been netted by a player still at the club.
Anthony Martial grabbed the winner in the 1-0 league victory at Old Trafford earlier this season and the Frenchman is priced at 11/4 (3.75) to score once more.
However, much more likely to be in the starting eleven is Marcus Rashford and he can also be backed at 11/4 (3.75) to score, although the 20-year-old has only managed two goals in 2018.
For Spurs, Christian Eriksen stands out at 3/1 (4.00) in the anytime scorer market with the Danish international in eye-catching form.
Tips and predictions
Eriksen has scored in three of Spurs' last four games and has netted an impressive 14 times this season, including against United at Wembley when he struck after just 11 seconds.
The price for him to score looks extremely tempting, while he is available at 9/1 (10.00) to open the scoring as he did the last time the sides met.