The Chile international has scored three goals in 14 games since joining the Red Devils in January, and can be backed at 9/2 (5.50) to open the scoring against his former club, or 5/4 (2.25) to strike anytime.
Lukaku to strike
However, having been on target in five of his last nine league matches, Romelu Lukaku looks like the best bet at 21/20 (2.05) anytime odds against a visiting backline that has not kept a clean sheet in their last seven on the road.
Having memorably struck twice on his senior league debut against this opposition, Marcus Rashford is available at 11/10 (2.10) to steal the headlines once again.
Laca on target?
At the other end of the pitch, Alexandre Lacazette will be hoping to maintain the strong form that has seen him hit seven goals in his last seven appearances.
Having scored in both of his previous two visits to this ground as an Arsenal player, Danny Welbeck could offer generous value at 15/4 (4.75) to come back to haunt his former club in this clash.
With eight goals to his name in the previous 10 fixtures, Aaron Ramsey is a tempting 6/1 (7.00) bet to hit the back of the net once again here, while Mesut Ozil is on offer at 13/2 (7.50) after scoring just once in 20 games for club and country.