Marcus Rashford is another who doesn't start, as Jose Mourinho reverts to a side which shows only two changes from the starting XI that attracted his ire in the 1-0 loss to West Bromwich Albion at Old Trafford last Sunday.
Sanchez was left out of the team against Bournemouth in midweek, while Pogba was playing for his spot following an early hook against West Brom.
But the Frenchman's Man of the Match display has ensured he gets the nod for the last-four encounter.
Harry Kane captains Spurs, with Michel Vorm replacing Hugo Lloris in goal. The England front man will be supported by an attacking midfield line of Christian Eriksen, Dele Alli and Son Heung-Min as the north London step out at their regular home ground.
As expected, there is no place in Mauricio Pochettino's starting line-up for defender Toby Alderweireld.
Manchester United: De Gea; Valencia, Jones, Smalling, Young; Matic, Herrera, Pogba; Lingard, Lukaku, Alexis.
Subs: J. Pereira, Lindelof, Mata, Fellaini, Darmian, Martial, Rashford.
Tottenham Hotspur: Vorm; Trippier, Sanchez, Vertonghen, Davies; Dier, Dembele; Eriksen, Alli, Son; Kane.
Subs: Lloris, Aurier. Alderweireld, Wanyama, Sissoko, Lamela, Lucas Moura.