Man City injuries
De Bruyne started at Leicester but made way for David Silva late on as he continues to step up his recovery from two separate knee injuries, but he did not travel with the squad to Southampton and City sources say he sustained a "knock" in training.
Ilkay Gundogan did not travel either, leaving City light in midfield.
Fernandinho is regarded as doubtful for the match, though his participation has not been completely ruled out.
Vincent Kompany has missed several games of late and appears no closer to a return.
Benjamin Mendy and Claudio Bravo are long-term absentees.
Man City suspensions
Fabian Delph is suspended, and Southampton have no suspensions.
Man City potential starting line-up
City should be able to welcome back David Silva to the starting XI but they have a number of headaches to contend with. Danilo has missed much of the season but could be called upon to start at right-back again given Kyle Walker's poor form, or he could fill in at left-back, instead of Oleksandr Zinchenko.
If Fernandinho is not fit enough to start then John Stones may have could deputise again, with Nicolas Otamendi partnering Aymeric Laporte at centre-back.
Things could change up front, but Riyad Mahrez has not started too many games of late, perhaps due to Mendy's injury meaning City's wingers need to stay wide rather than cut inside.
Possible City XI: Ederson, Walker, Otamendi, Laporte, Zinchenko; Stones, Bernardo Silva, David Silva, Raheem Sterling, Sergio Aguero, Leroy Sane.
Southampton Team News
Southampton's resurgence under Ralph Hasenhuttl took a blow on Thursday night as they lost at home to West Ham.
And the Saints could be without full-backs Ryan Bertrand (back) and Cedric (calf) for Sunday's game.
Opta match facts
- Southampton have won just one of their last 11 Premier League meetings with Manchester City (D2 L8), winning 4-2 in this exact fixture in the 2015-16 campaign.
- Manchester City have won their last four Premier League games against Southampton by an aggregate score of 12-2. They have never won five in a row against Saints in the Premier League.
- Man City have lost three of their last four Premier League games (W1) – as many as they had in their previous 70 in the competition (W55 D12 L3).
- After a run of six consecutive clean sheets, Man City have conceded in eight of their last nine Premier League games. The Citizens have conceded a goal with their first shot faced in three of their last four league games.
- Man City’s Raheem Sterling has been directly involved in 10 goals in his last 10 Premier League appearances against Southampton (6 goals, 4 assists), including scoring two and assisting two in the reverse fixture this season.
TV coverage and kick-off time
Kick off is 14:15 GMT (09:15 ET) on Sunday, and the game will be shown on Sky Sports in the United Kingdom. It will be shown on NBC and Universo in the United States, and on various channels around the world.