The Argentina international was introduced at half-time, however, in place of Philippe Coutinho and inevitably scored the goal to secure his club the Liga crown.
It took Messi 16 minutes to make his mark from the bench, beating two Levante defenders and firing the ball past the previously unbeatable Aitor Fernandez to mark his 34th league goal of the campaign.
The goal was Messi’s 24th as a substitute in La Liga, more than anyone else has managed in the 21st century.
It also secure Messi his 10th Liga title as a Barcelona player, surpassing the previous record held by Andres Iniesta (9).
Lionel Messi has beaten Andres Iniesta to become the Barcelona player with the most La Liga titles! 😍— Goal (@goal) April 27, 2019
Leo + trophies = true love 💜 pic.twitter.com/x0dYAYB6sx
Barcelona now look forward to a possible European trophy, but will have to overcome a double-headed tie with Jurgen Klopp's Liverpool to reach the 2019 final in Madrid.
Valverde's men eased past Ole Gunnar Solskjaer's Manchester United in the quarter-final stage of the competition, beating them 1-0 at Old Trafford and then 3-0 in the second leg at Camp Nou.
Liverpool promise to be a more formidable opponent, however, as they push for a Premier League and Champions League double under Klopp's guidance.