The England international has netted in all four of his top-flight appearances from the off at the ground, scoring five goals in those games.
Simon Mignolet returns in goal, Joe Gomez comes in for Trent Alexander-Arnold and Gini Wijnaldum is back at Newcastle for the first time since his switch last summer with Emre Can on the bench.
Jordan Henderson marks the 250th match of his Liverpool career, while Philippe Coutinho starts a fifth game in succession.
Newcastle, meanwhile, have made two changes to the side that lost to Brighton & Hove Albion last week.
Javier Manquillo comes in to replace Chancel Mbemba, while Jonjo Shelvey returns to the first 11, with Isaac Hayden dropping to the bench.
Newcastle United starting XI: Elliot, Yedlin, Lascelles, Clark, Manquillo, Ritchie, Merino, Shelvey, Atsu, Perez, Joselu
Newcastle United subs: Darlow, Gamez, Lejeune, Diame, Hayden, Murphy, Gayle
Liverpool starting XI: Mignolet, Gomez, Matip, Lovren, Moreno, Henderson, Wijnaldum, Coutinho, Salah, Mane, Sturridge
Liverpool subs: Karius, Klavan, Milner, Can, Oxlade-Chamberlain, Firmino, Solanke