The hosts boast an extremely strong home record, where they have lost only twice all season, and back in January they recorded a 1-0 Copa del Rey success over their more illustrious opponents.
Nevertheless, Madrid have won all five of their La Liga meetings with Lega and they will aim to keep that run going on Monday.
Mauricio Pellegrino's teamwon when they hosted Barcelona this term and are unbeaten in front of their own fans against any side currently in the top seven. The hosts are offered at 17/4 (5.25) with the draw at 16/5 (4.20).
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Real Madrid are without captain Sergio Ramos who is injured, while winger Vinicius Junior remains out. Right-back Dani Carvajal is likely to make his return from a muscular problem against his hometown club.
Leganes are without top scorer Youssef En-Nesyri, who has a knee injury.
Without a title on the line, the last few games of the season have become an exercise in professionalism for Real Madrid.
They are obliged to try and give strong performances, yet there is a distinct lack of tension and Leganes will feel they may never get a better chance to defeat Los Blancos in La Liga.
Madrid have struggled to make positive starts to matches recently and only one of their last 11 goals has come in the first half.
Early goals have also been a problem for the hosts, with Lega failing to score in the opening half in each of their last five encounters in the Primera Division.
Tips and predictions
A goalless first half is available at 12/5 (3.60) and this could attract some attention for a value bet. Opposing a goal before 26 minutes at 5/6 (1.83) also looks like a strong selection while under 2.5 goals in the game at 6/5 (2.20) could also appeal.
Odds correct at the time of writing. Please gamble responsibly.