With the quarter-finals getting underway this week, William Hill are 9/4 (3.25) on the Premier League champions being crowned the best side in Europe for the first time in their history.
While investment in the Citizens has brought domestic success in recent years, a European crown has so far eluded Pep Guardiola's team, but they have leading claims once again according to the odds compilers.
Having been instrumental in their comeback against Atletico Madrid last time out, Juve will hope to have the services of the competition's all-time leading scorer Cristiano Ronaldo for their first leg against Ajax.
The acquisition of the Portugal international saw the Italians as a popular pre-season selection with punters. The Dutch side are 33/1 (34.0) shots in the outright market after beating holders Real Madrid 5-3 on aggregate in the last 16.
That leaves the Catalan giants as the only La Liga representatives left in the running, with a team from the Spanish top-flight having won each of the previous five editions dating back to 2013.
Barca will have to get the better of a resurgent Manchester United if they're to progress to the next round albeit Ole Gunnar Solskjaer's side have experienced a dip in form since their dramatic comeback against Paris Saint-Germain in the last round. The Premier League team are 16/1 (17.0) in William Hill's latest Champions League winner odds.
Jurgen Klopp's side know the Portuguese champions well, having beaten them 5-0 over two legs in the first knockout round last season and while the margin of victory may not be so empahtic, the bookmakers expect a similar end result.