Erik ten Hag’s men pulled off an astonishing 4-1 win at the Santiago Bernabeu to see off Real Madrid in the previous round, overturning a 2-1 first leg home defeat.
Held to a 1-1 draw in front of their own fans last week, they are priced at 17/4 (5.25) with William Hill to pull off another upset by coming out on top at the Juventus Stadium.
However, the Bianconeri are unbeaten in 10 previous meetings between this pair, and are 4/6 (1.67) favourites to progress to the semi-finals for the third time in five seasons with a victory here.
Emre Can and Giorgio Chiellini could return after missing the first leg through injury, although Martin Caceres and Mattia Perin are all ruled out. Juve will make a decision on Mario Mandzukic's participation prior to the game after he picked up an injury. Douglas Costa may be fit enough for a place on the bench.
Frenkie de Jong is a doubt after coming off injured in Saturday’s 6-2 win over Excelsior, with Hassane Bande and Carel Eiting both long term absentees.
While a 1-1 home draw in the first leg would make most teams underdogs to progress against the Italian champions, this young Ajax team has repeatedly made fools of anyone who underestimates them so far this campaign.
Indeed, they have found the net in all nine of their fixtures in this season’s competition, putting four goals past Bayern Munich over two group matches and thfive past Real Madrid.
Therefore, they will have no fear of Massimiliano Allegri’s team, which has only kept two clean sheets in their last six Champions League games and lost two of their last five on home turf.
All in all, odds of 4/5 (1.80) are surely worth backing on de Godenzonen joining Juventus on the scoresheet in their fifth consecutive European clash with goals at both ends.