Jack Wilshere will captain the Gunners, while Danny Welbeck, Alexandre Lacazette and Alex Iwobi lead the line. Mesut Ozil has not been included in the travelling squad.
Elsewhere Chelsea have named both Alvaro Morata and Eden Hazard in their starting XI. The pair were rested for the FA Cup match against Norwich City, with Andreas Christensen, Victor Moses, Cesc Fabregas, N'Golo Kante and Cesar Azpilicueta also returning.
Azpilicueta captains Chelsea who are without Gary Cahill from their match day squad. Danny Drinkwater is a surprise inclusion in midfield.
David Luiz makes Chelsea's bench after coming back from injury in the FA Cup third round on Saturday.
Team to face Arsenal: Courtois; Azpilicueta (c), Christensen, Rudiger; Moses, Kante, Fabregas, Drinkwater, Alonso; Hazard, Morata. #CHEARS pic.twitter.com/jbcvsjsgXG — Chelsea FC (@ChelseaFC) January 10, 2018
Chelsea XI: Courtois; Azpilicueta (c), Christensen, Rudiger; Moses, Kante, Fabregas, Drinkwater, Alonso; Hazard, Morata
Chelsea subs: Eduardo, David Luiz, Zappacosta, Bakayoko, Willian, Pedro, Batshuayi
Arsenal XI: Ospina; Chambers, Mustafi, Holding; Bellerin, Wilshere, Xhaka, Maitland-Niles; Welbeck, Lacazette, Iwobi
Arsenal subs: Macey, Mavropanos, Mertesacker, Elneny, Nelson, Walcott, Alexis