Spurs have lost 18 and won none of their last 27 league visits to this stadium, although currently sit five points ahead of their hosts in the table.
However, Antonio Conte's men ran out 2-1 winners in August's reverse encounter at Wembley, and are 21/10 (3.10) favourites to complete the double over their London rivals for the first time since the 2005-06 season.
Just one of the previous 10 encounters between these teams has resulted in a draw, but you can get odds of 23/10 (3.30) on them cancelling each other out in this one.
Thibaut Courtois and Andreas Christensen are both available despite not playing their respective international sides, while Ross Barkley and David Luiz are still not fit and Ethan Ampadu is out for the rest of the season.
Toby Alderweireld is in contention after started for Belgium in midweek, while Son Heung-Min is expected to replace the injured Harry Kane up front.
Goals at both ends
Kane's early withdrawal through injury at Bournemouth last time out certainly did not do too much to hamper Mauricio Pochettino's men, who promptly scored four times to turn a 1-0 deficit into an emphatic 4-1 victory.
This bodes well for the game against the Blues, who have failed to keep a single clean sheet in any of their last six fixtures.
However, just four clean sheets in 17 away matches mean Tottenham will also struggle to keep things tight at the back against a Chelsea attack that has scored in 32 of their last 36 league home games.
All in all, odds of 3/4 (1.75) are well worth backing on both teams finding the net for the fifth time in six encounters.
There's also a huge new customer offer on this market. Anyone yet to sign up for a dabblebet account can get 6/1 (7.0) about both teams scoring in the match. What's more, all winnings are paid in cash, not free bets. £5 max bet. T&Cs apply.