Tite's team are unbeaten in 13 matches since being knocked out of the World Cup at the quarter-finals stage 12 months ago and the hosts are strong favourites to move into the final four of this competition at the expense of Eduardo Berizzo's men.
Indeed, William Hill make Brazil a 2/13 (1.15) chance to win this one inside 90 minutes.
Paraguay have won just one of their last 11 matches, reaching the last eight despite garnering just two points from their three group games.
Brazil fired five past Peru in their final group game. Roberto Firmino was on target against Los Incas and the Liverpool striker is expected to lead the line in Porto Alegre. Willian is pushing for a starting spot after coming off the bench to round off that drubbing.
Oscar Cardozo is expected to lead the line for Paraguay. The 36-year-old striker has scored seven goals in his last eight appearances for club and country.
Paraguay may find that attacking opportunities are at something of a premium here. Tite's team have conceded just two goals in 13 matches since their World Cup exit last summer.
Furthermore, Brazil have bagged a clean sheet in each of their last five fixtures and William Hill go 4/9 (1.44) that Berizzo's men fail to find the net in Porto Alegre. Brazil are available at just 4/7 (1.57) to win to nil with the same firm.
As well as that solid defensive platform, Brazil offer a genuine goal threat. Neymar's enforced absence appears to have had little adverse effect on Tite's men. Indeed, the Selecao have scored 14 goals in their five matches since the beginning of this month.
Paraguay can consider themselves as fortunate to have reached this stage of the competition. It seems likely, though, that Berizzo's side may see their luck run out here.
William Hill offer a tempting 7/5 (2.40) for Brazil (-2) to win this Copa America quarter-final by at least three goals. It is a selection that may well represent excellent value ahead of Thursday's tie.