This time round, the Terriers will host the Red Devils in the FA Cup fifth round at John Smith's Stadium on Sunday morning (AEDT), but will be without Mooy after he underwent knee surgery.
It's going to be a tough task for David Wagner's relegation-threatened team, especially considering they lost 2-0 to United at Old Trafford earlier this month - in an occasion marked by Alexis Sanchez home debut and first goal in Red.
Manchester United coach Jose Mourinho may use the match as a chance to give Sanchez a rest, considering the Chilean has started all four of the team's games since crossing from Arsenal at the end of January.
The declining form of Paul Pogba has been a huge concern for Mourinho, and it's likely the French midfield star will figure from the start in a bid to get him flowing again.
Opportunities may also be given to several fringe United squad players including Marcus Rashford, Ander Herrera and Matteo Darmian.
Wagner faces a selection dilemma up top between Beninese striker Steve Mounie and Belgian hitman Laurent Depoitre.
Mounie has hit the back of the net in his last two appearances for Town, but Depoitre was super impressive in a lone striker role against United in October's victory.
|BEST BET||VALUE BET|
|Manchester United to win, Huddersfield goalless at $2.30|
A draw at full time is paying $4.75 and will mean a replay between the two teams at Old Trafford later on in the season.
Manchester United have kept a clean sheet in their last six victories in all competitions, and a win to nil against the Terriers is paying a juicy $2.30.
You can expect Wagner's Huddersfield to try to keep it solid at home - you can get under 2.5 goals in match at $2.00.
*Prices subject to change