bet365 make Jurgen Klopp's side just 1/7 (1.14) to come out on top in their first fixture. The Reds were undefeated on home soil in the top-flight last term, winning 17 of their 19 outings.
The Canaries won the Championship to secure their return to the Premier League but at 16/1 (17.0) they are currently the biggest underdogs of the opening coupon.
4/6 (1.67) title favourites Manchester City are 1/4 (1.25) to beat West Ham in Saturday's early kick-off. Pep Guardiola's men have won their last seven competitive matches against the Hammers by a combined scoreline of 23-3 and it's 10/1 (11.0) that the hosts shock the reigning champions at the London Stadium.
Newcomers Sheffield United get their season underway with a trip to Bournemouth. The Blades have won their previous eight competitive games against the Cherries, albeit the last came in 2013.
Play-off winners Aston Villa have a tougher assignment, tasked with a trip to Tottenham Hotspur Stadium in the day's late kick-off. They're 12/1 (13.0) to leave the capital with three points while Spurs are just 2/9 (1.22) in the match odds market.
Newcastle are on the hunt for a new manager after announcing that Rafael Benitez will leave St James' Park at the end of his current contract. The Magpies face a tricky assignment to start the season and are 12/5 (3.40) underdogs to beat Arsenal.
The Gunners are 23/20 (2.15) having won 12 of their last 13 games against this opposition, but their away form left plenty to be desired last term. Indeed, Unai Emery's men lost eight times outside of the Emirates Stadium.
The blockbuster clash of the weekend comes as Manchester United (6/5) take on Chelsea (21/10) at Old Trafford. The Blues are also seeking a new name in the dugout after Maurizio Sarri's departure with Frank Lampard the red-hot favourite to take over at Stamford Bridge.
The Red Devils have struggled with the Blues in recent years, winning just two of their previous 13 Premier League meetings. Home advantage has helped though, with Ole Gunnar Solskjaer’s side unbeaten in six league games against the Londoners in front of their own fans.
Both teams face a serious battle for a top four spot according to the latest odds. United and Chelsea are each 11/10 (2.10) to end the season in the Champions League positions ahead of their meeting on August 11.
Odds correct at the time of publish. Please gamble responsibly.