Real Madrid and Barcelona will face off in El Clasico on October 24 and March 20 next season, after La Liga revealed their 2021-22 fixtures on Wednesday.
The two rivals finished behind champions Atletico Madrid last term and will look to overtake Diego Simeone's men in the upcoming season.
Espanyol, Mallorca and Rayo Vallecano meanwhile will all join La Liga in 2021-22 as newly promoted sides.
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When does La Liga start?
The first weekend of La Liga 2021-22 will be on August 15 and will end on May 22, after 38 rounds of matches.
Real Madrid will travel to Alaves on August 15 to kick off the season, while Barcelona will host Real Sociedad on the same day.
Atletico meanwhile will begin their title defence with an away fixture at Celta Vigo.
See the opening weekend fixtures in full below.
|August 15, 2021||Alaves vs Real Madrid|
|August 15, 2021||Barcelona vs Real Sociedad|
|August 15, 2021||Celta Vigo vs Atletico Madrid|
|August 15, 2021||Mallorca vs Real Betis|
|August 15, 2021||Cadiz vs Levante|
|August 15, 2021||Osasuna vs Espanyol|
|August 15, 2021||Sevilla vs Rayo Vallecano|
|August 15, 2021||Valencia vs Getafe|
|August 15, 2021||Villarreal vs Granada|
|August 15, 2021||Elche vs Athletic Club|
When are the Clasicos?
Barcelona will host the first Clasico of the season on October 24, as Real Madrid visit Camp Nou.
The return fixture will be held on March 20 as Carlo Ancelotti's side welcome Ronald Koeman's men to the Spanish capital.
When are the Madrid derbies?
The first Madrid derby of the 2021-22 season between Real and Atletico will be played on December 12, 2021 at Santiago Bernabeu.
Atletico host the second derby of the season on May 8, 2021 at the Wanda Metropolitano.
What happened in 2020-21?
Atletico Madrid won their first La Liga crown since 2014 last term, holding off Barcelona and Real Madrid to claim the title.
On the final day of the season, Atletico won 2-1 at Real Valladolid to clinch the title, finishing two points ahead of second-place Real and seven points ahead of Barcelona in third.