Barca have just pride to play for with the league title already secured, while their opponents are battling to secure fourth spot.
Ernesto Valverde has quite a job on his hands to try and rouse his troops after another humiliating European exit, and the visitors will surely feel this could be a good time to travel to Catalonia.
Nevertheless, the hosts are big odds-on favourites to record a win, priced at 8/15 (1.53) with bet365. Getafe are available at 5/1 (6.00) to claim what would be their first ever victory at the Camp Nou, with the draw offered at 10/3 (4.33).
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Barcelona are missing Luis Suarez with the striker undergoing surgery on a knee problem. Ousmane Dembele is also likely to be missing with a muscle problem, meaning the Blaugrana are a little depleted in the final third.
Getafe too have problems up front, with joint top scorer Jaime Mata suspended along with centre-back Bruno Gonzalez.
It could be extremely difficult for Barcelona to summon up the motivation required to face a combative and battling Getafe side, who have been one of the best teams in La Liga this term.
That Los Azulones are in pole position for a Champions League place is down largely to their home form, because on the road they have won just one of their last eight games.
However, the majority of their away results have been draws and they have only suffered three defeats away from the Coliseum Alfonso Perez all season. Against a deflated and depleted Barca side, they will feel they can avoid defeat once more.
Tips and predictions
Backing Getafe at +1.0 on the Asian handicap at 103/100 (2.03) looks like a strong option. This selection would pay out if Getafe win or draw, while our stake would be refunded if they lose by one goal.
We would only lose money if Jose Bordalas' side lose by two goals or more, something that has happened just twice in 18 away games this season.
Odds correct at the time of the writing. Please gamble responsibly.