Ernesto Valverde's side went behind at Stamford Bridge, but came back to earn a 1-1 draw as Lionel Messi scored against the Blues for the first time in his career.
The Blaugrana now turn their attentions back to the Primera Division as they look to take another step towards the title in an all-Catalan clash against Girona at Camp Nou.
Barca remain unbeaten in La Liga and lead second-placed Atletico by seven points after 24 rounds of matches, with Real Madrid 14 adrift in third spot...
Thomas Vermaelen is available again and the Belgium defender could feature on Saturday. Coach Valverde has a full squad at his disposal for the Camp Nou clash.
Nelson Semedo was suspended for the Champions League game against Chelsea on Tuesday, but he is available for this match and Valverde has no players banned this weekend.
BARCELONA POTENTIAL STARTING LINE-UP
Valverde has his entire squad available for this match and the Barca boss could opt to bring in fit-again Vermaelen in central defence in order to give Gerard Pique a rest.
After failing to feature for a single minute against Chelsea in the Champions League on Tuesday, summer signing Ousmane Dembele is in line to start on the right of midfield, while Philippe Coutinho (cup-tied in Europe) should feature on the opposite flank.
Luis Suarez will partner Lionel Messi in attack.
GIRONA TEAM NEWS
Girona are enjoying a superb season in this, their first ever campaign in La Liga. The Catalan club are in eighth place with 34 points, having won nine and drawn seven of their 24 games.
Pablo Machin's men have drawn twice against Atletico, while they also beat Real Madrid at home and impressed despite going down 3-0 to Barca at Montilivi earlier this season.
Defender Jose Raymundo Luis Suarez is sidelined, while left-back Johan Mojica is doubtful.
TV COVERAGE & KICK-OFF TIME
Barcelona versus Girona kicks off at 20:45 local time on Saturday and will be broadcast live in the UK (United Kingodm) on Sky Sports Football and also on Sky Sports Main Event, both from 19:40 GMT.
In the United States, the game can be watched live on television on beIN SPORTS and kicks off at 14:45 ET.
BEST OPTA MATCH FACTS
The reverse fixture this season was the first meeting between these two teams in La Liga, with Barcelona winning 3-0 at Montilivi.
Barcelona are unbeaten in their 19 Catalan league derbies played since February 21, 2009 (when they lost 2-1 at Camp Nou against Espanyol). However, they did lose 1-0 at Espanyol in the Copa del Rey this season, before winning the second leg 2-0.
Only one of Barcelona’s last 13 goals in La Liga was scored in the first half (Luis Suarez versus Eibar).
Of the current La Liga teams, Girona are the only one Messi is yet to score against.
After six away unbeatean games in La Liga (three wins and three draws), Girona have suffered back-to-back defeats on the road. They have yet to lose three consecutive away games in the top flight.