Since then, Diego Simeone's men have kept 11 consecutive home clean sheets and the Gunners know they must end that record to stand any chance of making the Europa League final.
Arsenal's scoring form on the road in the competition has been strong, though, as they have netted at least twice in all three of their away matches in the knockout stages.
It was Arsenal's top scorer this season Alexandre Lacazette who netted in the first leg last week and bet365 price the Frenchman at 12/5 (3.40) in the anytime goalscorer market.
Certainly, if the Gunners are to find the back of the net, Lacazette seems the most likely to score with the 26-year-old netting in each of his last three games.
Arsenal's top scorer in the Europa League is Aaron Ramsey with four strikes, all of which have come in the knockout stages and three of them away from home.
Costa returns against a familiar opponent
During his time at Chelsea, the Spaniard enjoyed his matches against Arsenal with three goals in six appearances against them, although since rejoining Atleti in January he has only netted six times in all competitions.
Tips and predictions
The most in-form player on the pitch, however, is Antoine Griezmann with the 27-year-old having netted four Europa League goals this term.
Griezmann will surely start once more on Thursday and the price of 11/10 (2.10) for him to score is hard to ignore considering his 27 goals in all competitions.
Saul Niguez also remains an attractive value bet option at 15/4 (4.75) to score his fourth Europa League goal of the season, considering his penchant to score in big games.
Prices correct at time of writing. Please gamble responsibly.