Athletic, though, have won three of their last four games to put themselves in contention for a Europa League spot and Gaizka Garitano's side remain extremely difficult to beat at San Mames.
Athletic Club vs Real Madrid Latest Odds
Real Madrid have only won two of their last six matches in Bilbao, with their last two visits there ending in draws.
Athletic Club vs Real Madrid Team News
The hosts will be without midfielder Benat Etxeberria but otherwise have few injury concerns.
Real Madrid's only injury absentee looks set to be Nacho Fernandez. Eden Hazard was rested for the game against Getafe and is likely to come back into the matchday squad for the weekend.
Athletic Club vs Real Madrid Preview
This game sees La Liga's best defensive side visit the team with the third-best defensive record in the division and a low-scoring encounter in Bilbao looks guaranteed.
Indeed, San Mames which has seen the fewest number of goals in La Liga this season, with Athletic having netted 20 times and let in just nine strikes.
With Athletic conceding the fewest goals at home and Real Madrid the fewest goals on the road, there should be plenty of interest in opposing a goal fest in the Basque Country, and it is Los Blancos' defensive solidity upon which they have based their title push.
Going forward, Madrid are likely to be tired after a draining game against Getafe on Thursday evening and Zidane's men know they will be in for another battle on Sunday against robust and resolute opposition.
Athletic Clubs vs Real Madrid Tips And Predictions
The price of 4/5 (1.80) for under 2.5 goals should be of real interest, with Athletic's games averaging the second lowest number of goals in the Spanish top flight.
Also worthy of consideration is backing under 1.5 goals at 5/2 (3.50) which has paid out in Madrid's last two games.
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Odds correct at the time of writing. Please gamble responsibly.