The Gunners and the Hammers have accumulated a grand total of zero points so far in the Premier League, going down to back-to-back defeats on the opening two weekends.
Unai Emery's men in particular will hope for better fortunes in their second game at the Emirates Stadium after losing their opener to reigning champions Manchester City.
There have been signs the Emery revolution is beginning to take effect, but will it be enough to down a West Ham team who also have a point to prove on Saturday?
|Game||Arsenal vs West Ham|
|Date||Saturday, August 25|
|Time||3pm BST / 10am ET|
TV Channel, Live Stream & How To Watch
In the United States (US), the game will be shown on NBC Sports and livestreamed on NBC Sports Live .
|US TV channel||Online stream|
|NBC Sports||NBC Sports Live|
In the United Kingdom (UK), the game will not be televised due to regulations banning the broadcast of 3pm kick-offs.
Squads & Team News
|Goalkeepers||Cech, Leno, Martinez|
|Defenders||Bellerin, Sokratis, Lichtsteiner, Mustafi, Holding, Monreal, Mavropanos|
|Midfielders||Elneny, Mkhitaryan, Ramsey, Torreira, Ozil, Iwobi, Guendouzi, Xhaka|
|Forwards||Lacazette, Aubameyang, Welbeck|
Unai Emery has made one change to his starting XI from the team that lost to Chelsea, introducing Aaron Ramsey for Mesut Ozil, who has flu and is absent.
Laurent Koscielny and Sead Kolosinac are on the sidelines as the defenders recover from Achilles tendon and knee injuries respectively.
Ashley Maitland-Niles is also unavailable, having fractured his left fibula during the 2-0 defeat to Manchester City.
Arsenal XI: Cech; Bellerin, Mustafi, Sokratis, Monreal; Guendouzi, Xhaka; Mkhitaryan, Ramsey, Iwobi; Aubameyang.
|Position||West Ham squad|
|Defenders||Fredericks, Zabaleta, Ogbonna, Diop, Balbuena, Rice, Cresswell|
|Midfielders||Masuaku, Noble, Obiang, Wilshere, Sanchez, Anderson|
|Forwards||Antonio, Yarmolenko, Snodgrass, Arnautovic, Perez, Hernandez,|
West Ham have made four changes to their starting XI, meanwhile. Pablo Zabaleta, Angelo Ogbonna, Mark Noble and Javier Hernandez drop out of the team beaten by Bournemouth a week ago, with Issa Diop, Ryan Fredericks, Carlos Sanchez and Michael Antonio coming into the team.
The Hammers remain without long-term injury victims Winston Reid, Manuel Lanzini and Andy Carroll, but otherwise Manuel Pellegrini has a full-strength squad to choose from for the visit to the Emirates.
Potential West Ham XI: Fabianski; Fredericks, Diop, Balbuena, Masuaku; Sanchez, Wilshere; Snodgrass, Antonio, F. Anderson; Arnautovic.
Betting & Match Odds CHECK THIS BEFORE PUBBING
Arsenal are priced at odds of 4/11 to win according to bet 365 , while a draw is available at 9/2. A win for West Ham is priced at 8/1.
Click here to see all of bet 365 's offers for the game, including goalscoring markets, correct score predictions and more.
After all the tension and excitement of 'Wenger Out', Arsenal fans are quickly learning that a new face on the bench is no guarantee of success.
Wenger's replacement Emery was perhaps unfortunate to face two heavyweights in the shape of Manchester City and Chelsea in a Premier League baptism of fire.
But the bare statistics do not lie: after two games Arsenal have failed to pick up a point, scoring just twice and conceding a worrying five goals from that daunting pair of fixtures.
At least against Chelsea there were signs that the ex-Sevilla and PSG coach has the means to turn it around. Arsenal fought back from two goals down at Stamford Bridge and were unlucky to see Marcos Alonso seal a late win for the Blues.
Still, he will be demanding far better at home to West Ham, exactly the kind of game in which the Gunners have no room for error if they want to reclaim a place in the Champions League come May.
Manuel Pellegrini, however, will also be keen to turn around his side's failing fortunes after defeats against Liverpool and Bournemouth saw the Hammers join Arsenal, Fulham and Huddersfield in the Premier League basement without a single point.
West Ham spent big over the summer, and the onus will be on the likes of Felipe Anderson, former Gunner Jack Wilshere and Andriy Yarmolenko to prove they were worth the outlay.
There is certainly no shortage of talent in the east Londoners' squad, although they will have to be at their absolute best to deny the Gunners their maiden win of the season and further pile pressure on Emery.