Arsene Wenger's men led 1-0 against AFC Bournemouth at Vitality Stadium last weekend but the loss of two goals in four second half minutes saw the Cherries come from behind to heap yet more misery on the north Londoners.
Arsenal have failed to win any of their last five fixtures - with their last victory coming against Saturday's opponents at Selhurst Park last month - and despite a disappointing dip in results since that 3-2 win in south London, dabblebet make the Gunners their 4/7 (1.57) favourites to pick up all three points this weekend.
Palace, though, will not be a pushover as they have lost just one of their last 12 Premier League matches - the reverse against the Gunners - while Roy Hodgson's side have put together a five-match unbeaten run away from home in the Premier League.
An away win can be backed at a chunky 5/1 (6.0) with dabblebet ahead of this match, while the same firm go 100/30 (4.33) that the two teams are forced to settle for a share of the spoils at Emirates Stadium.
Alexis Sanchez was the architect of Palace's downfall when these teams met in December when he scored twice in that match for the Gunners, but he will almost certainly be a notable absentee on this occasion for his immediate future is far from certain.
The Chilean was left out of Arsenal's squad at Bournemouth last weekend and even if he remains an Arsenal player by Saturday afternoon, there is no guarantee that he will feature, whilst Laurent Koscielny and Nacho Monreal could make their returns this weekend.
Palace are plagued by an injury crisis with Andros Townsend, Jeffrey Schlupp, Mamadou Sakho, Joel Ward, Scott Dann and Jason Puncheon all likely to miss the match against Arsenal.
The last meeting between these two sides was a fantastic five-goal thriller and there is evidence to suggest that the goals could flow once again when this rivalry is renewed in north London.
Each of Arsenal's last five league matches has seen goals at both ends, with more than two goals scored on four occasions, and dabblebet offer 8/13 (1.62) that both teams are on target this time around, while the same firm go just 4/7 (1.57) that there are at least three goals scored when the Gunners host the Eagles.
Having scored just one goal in their opening nine away matches in all competitions, Palace have found the net in each of their last four fixtures on their travels and dabblebet go just 1/2 (1.50) that the Eagles score a goal here.
The same firm also offer 9/4 (3.25) that Hodgson's side manage more than one goal, which could pay dividends as Arsenal have conceded two or more goals in five of their last seven matches and have looked far from assured at the back in recent weeks.
Tips and predictions
Palace will feel that they can hurt the vulnerable hosts in north London but, even without Sanchez, the Gunners are capable of getting amongst the goals and so dabblebet's 13/10 (2.30) quote for at least four goals to be scored on Saturday could represent good value for punters.