Unai Emery's side are coming into the game in fourth place on goal difference following Bournemouth's 4-0 hammering of Chelsea but must be wary of a City backlash.
A strong City team were defeated 2-1 in Newcastle in midweek; a loss which saw the title holders slip five points behind Liverpool in the chase for the Premier League trophy.
Moreover, Arsenal's away form in the league is not promising. They have not won in five games on the road since beating Bournemouth back in November.
There has been a boost in Arsenal's injury department with the news that captain Laurent Koscielny's facial injury picked up against Manchester United in the FA Cup fourth round defeat is not as bad as first feared. He has reportedly returned to full training and could well come into a backline which is desperately lacking in numbers.
Hector Bellerin and Rob Holding are longer-term casualties while Sokratis Papastathopoulos will miss two or three more weeks with his ankle injury.
Henrikh Mkhitaryan is pushing closer to fitness after a broken metatarsal while Ainsley Maitland-Niles is also due to be assessed in the days before the fixture after missing out against Cardiff with a knee injury.
Danny Welbeck is out for the rest of the season.
Arsenal have no suspended players for this match.
Possible Arsenal Starting Line-Up
Emery could well decide to field Koscielny now that he has returned to full training and he would be expected to team up with Shkodran Mustafi in the heart of the Gunners' defence.
It remains to be seen whether or not Mesut Ozil will retain his place in the team after starting in midweek against Cardiff. He played in the opening day defeat by City at the Emirates but the coach has not always preferred to use the German against top six opposition since then.
Aaron Ramsey could come back into the fold after missing the Cardiff game while Granit Xhaka will also be pushing for a start.
Manchester City Team News
Ederson suffered an injury believed to be a cut or a gash against Newcastle on Tuesday night with reserve goalkeeper Aro Muric in line to replace him from the bench at one stage. The Kosovo international will be expected to deputise if Ederson doesn't make it.
Defenders Benjamin Mendy and Vincent Kompany are still not match fit and neither is expected to start.
Mendy has suffered a complication on his return from a bad knee injury while a niggling muscle problem is plaguing the club captain.
TV Coverage & Kick-Off Time
The game will be shown live in the UK on Sky Sports Premier League, Sky Sports Main Event and Sky Sports Ultra HD and is available to stream on NOW TV and SKY GO. It kicks off at 16:30 GMT (11:30 ET) . It will be available to watch live in the United States on NBC Sports Live.
Best Opta Match Facts
- Manchester City have won their last three Premier League games against Arsenal – they’ve haven’t won four consecutive top-flight games against the Gunners since April 1937.
- Arsenal have lost seven of their last 11 visits to the Etihad Stadium in all competitions against Man City (W2 D2), losing the last two.
- Manchester City have lost four of their last nine Premier League games (W5), as many as in their previous 72 combined (W56 D12).
- Arsenal have lost 11 of their last 19 away Premier League games (W5 D3), keeping just one clean sheet in that time, a 1-0 win at Huddersfield Town in May 2018.
- Since Roberto Firmino’s goal for Liverpool on January 3rd, Manchester City have scored 25 goals in a row without conceding at the Etihad in all competitions, winning their last four home games by an aggregate score of 24-0.
- Manchester City have lost three of their last seven Premier League games when scoring first – they had lost just three of their previous 96 matches when scoring the first goal.
- Pierre-Emerick Aubameyang scored his 25th Premier League goal in Arsenal’s last match against Cardiff, reaching that number faster than any other Gunners player in the competition’s history (37 games).
- Since August 20th, Manchester City have only won three more points in the Premier League (50) than Arsenal (47) and have lost more games (4) than the Gunners (3) in that time.
- Manchester City manager Pep Guardiola has never lost a match against Unai Emery in all competitions (W7 D4 L0) – the only manager he has faced more during his managerial career without losing is Joaquín Caparrós (13 games).
- Sergio Aguero has scored in seven of his last 11 matches against Arsenal in all competitions for Manchester City, though he hasn’t found the net in either of his last two.
- Since Pierre-Emerick Aubameyang’s Premier League debut (February 3 2018), Aubameyang and Alexandre Lacazette have combined for seven Arsenal goals in the competition – two more than any other duo for the club in that time.