Lionel Scaloni's men went down 2-0 to Colombia in their opener, a result that leaves them bottom of Group B after the opening round of fixtures.
Having run out emphatic 6-1 winners against this opposition in their previous Copa America clash back in 2015, Argentina are 4/9 (1.44) favourites with bet365 to get back on track with a crucial victory here.
However, La Albirroja pulled off a 1-0 win in the most recent meeting between this pair, and are priced at 13/2 (7.50) to come out on top once again in Belo Horizonte.
Two of the last four encounters between these teams have resulted in draws, and you can get odds of 16/5 (4.20) on this one also finishing up all square.
Scaloni is likely to make changes following the disappointing display against Colombia, with Angel Di Maria unlikely to keep his place after being subbed off at half-time.
Derlis Gonzalez will be hoping to start after coming off the bench to score the opener in his side's 2-2 draw with Qatar.
Whatever changes the manager makes, it is hard to see them having an immediate impact considering his side’s recent performances.
Just five of the Albiceleste’s last 15 goals have arrived in the first half, while they have failed to find the net before the break in three of the most recent four.
What’s more, Eduardo Berizzo’s team has only conceded in the opening 45 minutes in three of their last 12 matches, so should be confident of putting up a stubborn resistance against their neighbours.
All in all, odds of 21/20 (2.05) look like solid value on the majority of the goalmouth action not unfolding until after half-time for Argentina’s fourth consecutive game, as well as a third in succession for Paraguay.
All odds corect at time of publish. Please gamble responsibly.