After sealing their place in the Champions League knockout stage, Manchester United will be aiming to get their faltering Premier League campaign back on track when they travel to Southampton on Saturday.
Last weekend's frustrating goalless draw at home to Crystal Palace left the Red Devils seven points adrift of the top four, with just three wins to their name in eight league fixtures.
However, having won five and lost none of their last seven league visits to St Mary's, they are 88/100 (1.88) favourites with William Hill to collect a much-needed three points here.
Meanwhile, Mark Hughes' men are third from bottom with just eight points from a possible 39, but are available at 10/3 (4.33) to pull off a shock win over his former side.
Four of the hosts' six home matches this season have resulted in draws, and you can get odds of 5/2 (3.50) on them claiming a valuable point in this one.
Victor Lindelof faces around a month on the sidelines after picking up a thigh injury against Crystal Palace last weekend, although Diogo Dalot and Marcos Rojo are back in training following lay-offs.
Danny Ings faces a late fitness test as he looks to shake off a hamstring injury, while Sam Gallagher and Shane Long both remain injured.
While there is plenty of speculation about Jose Mourinho's job security, he is way behind Hughes in the current sack race betting.
This is no surprise given his team's form, with the Saints having won just a single game so far this league campaign - the lowest tally in the division.
It has been particularly bleak at home, where they are without a home win all season and have come out on top just once in 17 league fixtures.
Having pulled off victories over Juventus and an impressive Bournemouth side, as well as holding Chelsea to a draw in recent away games, those 88/100 (1.88) odds seem very generous on even an under par United coming out on top against struggling Southampton.