The Spaniard has taken the reins after Arsene Wenger's record 22 years at the club came to an end this summer, a spell that brought three league titles and seven FA Cups.
However, his new side are 14/5 (3.80) underdogs with bet365 to get off to a winning start against last season's runaway league champions.
Indeed, the Citizens finished 37 points clear of their guests last campaign, so are understandably 19/20 (1.95) favourites to ruin the occasion by coming out on top in North London.
Three of the last five league encounters between this teams at this ground have resulted in draws, and you can get odds of 3/1 (4.00) on them cancelling each other out once again in this one.
Sead Kolasinac is out with a long term injury, while Nacho Monreal and Aaron Ramsey will both face late fitness tests after suffering slight setbacks.
Danilo and Eliaquim Mangala are both ruled out through injury for Pep Guardiola, who will decide whether to start Raheem Sterling and Kevin De Bruyne after their late return to training following the World Cup.
After a positive transfer window and impressive pre-season results, even the most pro-Wenger fans would find it hard not to be excited about a fresh start under Emery.
However, the former Paris Saint-Germain boss could hardly have asked for a more difficult start to life in England than a game against a team described last season as potentially the Premier League's best ever.
Having lost all three of the encounters between the teams last season by at least two clear goals, this new-look Arsenal has a massive job on its hands to close the gap.
With City having looked sharp in easing to a 2-0 Community Shield victory over Chelsea last weekend, those 19/20 (1.91) odds look good value on them picking up where they left off and coming out on top against an opponent still in the early stages of transition.
Odds correct at the time of writing. Please gamble responsibly.