Ahmed Fathy's own goal, Denis Cheryshev and Artem Dzyuba efforts in the second half put Stanislav Cherchesov's side in control at the Krestovsky Stadium.
And Mohamed Salah reduced the deficit for the north Africans with his effort from the penalty spot but it was not enough to stage a comeback for the former African champions.
However, football fans have taken to social media to react after the game.
World Cup is 30 days. How can you leave the tournament after just 5 days Egypt?— Saddick Adams Obama (@SaddickAdams) June 19, 2018
So disappointed Egypt didn't play Salah in that 1st match— Mike LaBelle (@MikeLaBelle) June 19, 2018
Egypt going out the World Cup in embarrassing fashion. No Salah magic, at least Ronaldo / Messi have something to work with their squads, these Egyptians are dire.— Hesham Bilal-Hafiz (@hesham786) June 19, 2018
The only thing Egypt can hold captive is the Israelites. Football ain't meant for them. #RUSEGY— Mr. Gitz (@iGitz_) June 19, 2018
Goodbye Egypt— Diego Farromeque (@di3g0ooo) June 19, 2018