Jurgen Klopp's side also come off the backs of an emphatic 3-2 win against Paris Saint-Germain in the Champions League, with Roberto Firmino netting the winner deep into stoppage time after coming on as a second-half substitute.
The Reds have not won six games in a row in the Premiership era, with only Chelsea matching their five-game winning streak.
|Game||Liverpool vs Southampton|
|Date||Saturday, September 22|
|Time||3pm BST / 10pm EST|
TV Channel, Live Stream & How To Watch
In the United States (US), the game will be shown on NBCSN and streamed online via the NBC Sports Live app.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
In the United Kingdom (UK), the game will not be televised.
|UK TV channel||Online stream|
Squads & Team News
|Goalkeepers||Alisson, Mignolet, Kelleher|
|Defenders||Clyne, Gomez, Van Dijk, Moreno, Alexander-Arnold, Robertson, Klavan|
|Midfielders||Jones, Fabinho, Milner, Keita, Shaqiri, Wijnaldum, Markovic, Henderson|
|Forwards||Sturridge, Firmino, Mane, Salah, Solanke|
Roberto Firmino has made a full recovery from the eye injury sustained during the 2-1 win at Tottenham and comes into the starting XI for Daniel Sturridge. Joel Matip and Xherdan Shaqiri replace Joel Matip and James Milner respectively.
Dejan Loven still remains on the fringe of returning to training.
Alex Oxlade-Chamberlain remains sidelined with a long-term injury.
Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Henderson, Wijnaldum, Shaqiri; Mane, Firmino, Salah
|Goalkeepers||McCarthy, Gunn, Lewis, Forster|
|Defenders||Soares, Yoshida, Vestergaard, Stephens, Hoedt, Bertrand, Targett, Bednarek, Valery|
|Midfielders||Davis, Elyounoussi, Romeu, Ward-Prowse, Armstrong, Lemina, Redmond, Hojbjerg,|
|Forwards||Long, Austin, Gallagher, Gabbiadini|
Danny Ings will not be in the side to face his former club as a loanee, while Manolo Gabbiadini is still on the cusp of a return from a hamstring injury.
Southampton XI: McCarthy; Cedric, Vestergaard, Hoedt, Targett; Lemina, Romeu; Redmond, Hojbjerg, Bertrand; Long
Betting & Match Odds
Liverpool are priced at odds of winning 2/9 according to bet 365, while a draw is available at 13/2. A win for the Saints is priced at 18/1.
Klopp's current side have received criticism for not putting goals away as clinically as they did last season, with accusations of Mohamed Salah and Sadio Mane not doing their best in the final third, but that hasn't stopped the Reds from picking up five consecutive Premier League wins.
Liverpool head into the home fixture against the Saints buoyed by two massive victories against the high-profile likes of Tottenham and PSG, with both matches won through narrow one-goal margins.
A home fixture against 13th-placed Southampton may just be what Salah needs to regain momentum and form, though his two goals and two assists this season are the same as what he achieved this time last year.
The Egyptian was undeniably frustrated to have been unable to score against Tottenham and PSG which left the likes of Firmino, Daniel Sturridge and Giorginio Wijnaldum stepping up in his goal-scoring absence.
Sturridge made his first ever Champions League start for Liverpool against PSG and scored, drafted in as first-choice forward ahead of Firmino who sat out the first half due to an eye injury.
The former Chelsea man may be putting pressure on competition for the front-three, ahead of what could be several key clashes with Liverpool over the next few weeks– including Chelsea twice in the league and Carabao Cup, Manchester City and an away trip to Napoli.