Zinedine Zidane surprised many when leaving Cristiano Ronaldo out of the squad to face Sevilla in the first leg, yet the bold move seemed to be vindicated by Madrid securing a 3-0 win.
Ronaldo is once more missing against his favourite opponent with the Ballon d'Or winner unable to add to his tally of 22 strikes in 15 games against the Andalusians. Also rested last week was Karim Benzema with the Frenchman an unused substitute at the Bernabeu, with his place taken by Alvaro Morata.
Zidane is likely to stick with Morata for tonight's side and the Spain international is offered at 13/10 (2.30) - just behind Benzema who can be backed at evens (2.00). Also missing from the squad is James Rodriguez who scored twice in the first leg, with attacking midfielder Isco also joining the Colombian on the sidelines.
This should mean a place in the side for Marco Asensio who scored in spectacular fashion against Sevilla in the UEFA Super Cup and is offered at 7/2 (3.50) to do so once more. Meanwhile, Lucas Vazquez could also feature after recovering from injury and the 25-year-old can be backed at 11/5 (3.20) to score his first ever Copa del Rey goal for Real Madrid.
For their part, Sevilla know they need goals to make this second leg is any way competitive and Saturday night saw them record an impressive 4-0 win away at Real Sociedad.
French striker Wissam Ben Yedder recorded a hat-trick at Anoeta to take his tally to 15 goals for the season, and while he did not start the first leg, the former Toulouse forward will surely be selected by manager Jorge Sampaoli given the side's need for goals.
Ben Yedder is priced at 7/5 (2.40) to find the back of the net and that looks appealing given his form, perhaps more so than the price of 13/10 (2.30) for Luciano Vietto to score, with the Argentine netting in just one of Sevilla's last seven league games.
Elsewhere for the hosts, midfielder Pabo Sarabia scored his fourth league goal of the weekend and is offered at 11/4 (3.75) to find the back of the net against his former club, while towering utility man Vicente Iborra can be backed at 7/2 (4.50) with aerial threat from set-pieces notable.