Despite a disappointing 2-1 defeat against Hull City, Jose Mourinho's men booked their place in the EFL Cup final on Thursday night, winning 3-2 on aggregate against the Tigers and the men from Manchester can enjoy yet more Cup cheer against the Latics this weekend.
United are unbeaten in 16 home matches in all competitions and the hosts are as short as 3/20 (1.15) with Betfair Sportsbook to extend that run with a win against Wigan on Sunday afternoon.
Betfair have lined up a new customer enhanced offer for this game. Anyone opening an account with the online firm can back United at a massive 5/1 (6.0) to win in normal time. Simply use the link provided to register, back the red-hot favourites at the usual price shown on site and if they win, the returns will be topped up to the value of 5/1 (6.0). Winnings paid in free bets. T&C's apply.
Given that the Latics are above the Championship relegation zone only by virtue of their superior goal difference, preserving their place in the second tier of English football is undoubtedly Wigan's primary priority for the remainder of the campaign.
Warren Joyce's side, however, have an impressive record in this competition; Wigan have lost just two of their last 16 FA Cup ties inside 90 minutes - against Bolton Wanderers and Bury respectively - and the Latics were Cup winners in 2013, before bowing out of the competition at the semi-final stage to eventual winners Arsenal the following season.
Wigan, too, come into this match in decent form, having recorded three successive victories in all competitions for the first time this term, conceding just two goals in their last five fixtures.
The assignment facing the Championship club on this occasion, however, is huge and, indeed, the enormity of the task ahead is reflected by Betfair Sportsbook's 16/1 (17.0) quote for Joyce's charges to claim a famous victory at Old Trafford, while the same firm go 6/1 (7.0) that the Latics earn a replay against the Cup holders.
Mourinho's men, however, have a tremendous record in the FA Cup; United have lost just one of their last 40 ties against lower league opposition in this competition, while the men from Manchester have lost just one of their last 12 fourth round fixtures.
A 4-0 demolition of Reading in the previous round has set the tone for this Cup campaign and Manchester United, beaten in just one of their last 13 FA Cup matches, should cruise to a comfortable victory against the Latics this weekend.
Mourinho's charges can be backed at a juicy 6/5 (2.20) to win by three clear goals; the 54-year-old Portuguese will demand a response to Thursday's limp loss against Hull City from his side and, given the gulf in class between the teams, United are good value to claim a convincing victory against the Latics in Sunday's FA Cup clash from Old Trafford.