The Blues were beaten by Manchester United at Old Trafford last weekend - a result that saw Mauricio Pochettino's team close the gap at the top of the Premier League table to four points - and in-form Spurs will surely come into this Cup clash in confident mood.
Remarkably, Tottenham have lost each of their last six FA Cup semi-finals and, so, it has been 26 years since Spurs reached the final of this competition and there is 8/5 (2.60) that Chelsea prolong the agony for the north Londoners by winning inside 90 minutes.
Spurs are in superb form; Pochettino's team have won each of their last eight matches and have suffered just one defeat in their last 21 domestic matches; the north Londoners, however, played four fixtures at Wembley in European competition this season and won just one of them.
As such, Tottenham will arrive at the national stadium determined to banish the bad memories of those matches at Wembley earlier in the campaign and the team from White Hart Lane are certainly equipped for the task.
Pochettino's squad is packed with talent; Spurs possess genuine quality in attack but the also boast the best defensive record of any team in the top tier of English football this season having conceded just 22 goals in the league, while Spurs have kept a clean sheet in three of their previous four FA Cup ties this term.
Chelsea have conceded in all but one of their last 11 matches against teams from the top tier and that is certain to be a cause for concern for Conte ahead of this Cup clash - particularly with Spurs in such fantastic form in front of goal.
Tottenham have scored more than two goals in seven of their last nine domestic games, bagging eight without reply in their last two Premier League matches; furthermore, Spurs have hit 15 FA Cup goals in just four FA Cup clashes so far this season.
The 13/8 (2.63) quote, therefore, for Spurs to score more than once could be a solid selection, with 11/10 (2.10) that there are more than two goals scored when these teams meet; 4/5 (1.80) is available that there are goals scored at both ends.
Despite suffering a setback against Manchester United, the Blues remain on course for a domestic double and Chelsea undoubtedly have the ability to put the bitter disappointment of defeat against Jose Mourinho's men behind them with aplomb at Wembley.
Spurs, though, are full of belief and bet365's 7/4 (2.75) quote for Mauricio Pochettino's team to come out on top in this Cup clash could offer good value for punters.