Paul Cooke’s team already has one Premier League scalp to their name in this season’s competition, beating Bournemouth 3-0 in a replay in the last round.
Having won each of their last three home games against this opposition while in the top flight, they are available at 31/20 (2.55) with bet365 to record another shock victory in front of their own fans.
However, the Hammers are unbeaten in seven fixtures in all competitions, and are 13/8 (2.63) favourites to take their place in the last 16 by coming out on top in this one.
The hosts have needed replays to make it through both of the last two rounds after drawing the original ties, and there are odds of 12/5 (3.40) on offer on them playing out another stalemate here.
Although he made his debut in last weekend’s 3-1 victory over Plymouth, new signing James Vaughan is cup tied and not available for the Latics.
With Manuel Lanzini and Marko Arnautovic having joined Andy Carroll on the sidelines, David Moyes will once again field a significantly rotated line-up for the cup.
No cutting edge
The absence of both Lanzini and Arnautovic is bad news for Moyes as his men struggled in the last round against League One Shrewsbury without them, with no goal being scored until extra-time in the replay.
Having kept six clean sheets in their last seven home games, Wigan are more than capable of frustrating their weakened Premier League opponents.
However, they may struggle for firepower themselves after failing to score in three of the most recent four.
Tips and Predictions
With West Ham having conceded just three goals in their previous five fixtures, odds of 4/5 (1.80) seem generous on no more than one team finding the net.
All odds correct at time of writing. Please gamble responsibly.