Pascal Gross’ goal saw the Red Devils went down 1-0 away to Brighton on Friday, their second defeat in four league fixtures.
However, having won 13 and lost just one of the previous 18 encounters between these sides, they have been boosted to an industry-best 17/20 (1.85) from 4/5 (1.80) with dabblebet to return to winning ways at the first attempt.
None of the guests’ last 15 league fixtures have resulted in draws, but there are odds of 13/5 (3.60) available on them being held to a stalemate in this one.
Winston Reid, Sam Byram and Michail Antonio all remain on the sidelines for the Hammers, although Pedro Obiang and James Collins could be involved after returning from injury.
Sergio Romero, Alexis Sanchez and Phil Jones are all doubts after missing the Brighton defeat, whilst Romelu Lukaku is out for United's final two league games with an ankle injury.
Motivated Red Devils
Although defeat at the Amex Stadium was disappointing for Jose Mourinho, it is unlikely to prove particularly significant as his team need just one point from the remaining two games to clinch second place.
Having won seven of their last nine league games, those boosted 17/20 (1.80) odds are well worth backing on United coming out on top for the fourth match in a row against a West Ham side with nothing to play for.