Despite having won just two of their last 11 league matches, the Hammers are in a decent position as they bid to preserve their Premier League status.
David Moyes' men sit six points above the drop zone and victory here would certainly represent a significant step towards safety.
West Ham have been beaten in just two of their last 12 matches on home soil and are chalked up as an 17/2 (9.50) chance with dabblebet to beat Pep Guardiola's men in east London.
City have already wrapped up the title but victory here will see Guardiola's side move onto 30 wins for the season and equal the record number of Premier League wins in a single season.
Given their utter dominance in the competition this term, it is no surprise that City are available at just 1/3 (1.34) to win this one, while the same firm go 9/2 (5.50) that the match ends all square.
Fernandinho is available again after serving a suspension against Swansea City whilst Benjamin Mendy came off the bench last week and is pushing for a start. John Stones and Sergio Aguero are out.
Joe Hart cannot play against his parent club, so Adrian will be in goal for the Hammers.
James Collins could return for the Hammers, but Michail Antonio, Winston Reid, Sam Byram and Pedro Obiang are all out.
A tight tussle?
Five of the last seven matches at London Stadium have seen fewer than three goals scored and dabblebet go 7/5 (2.40) that the trend continues in this clash.
Furthermore, there have been goals at both ends in just one of West Ham's last four home matches and dabblebet offer 10/11 (1.91) that either side fails to find the net.
Manchester City, though, have scored 11 goals in their last four Premier League fixtures away from home and they smashed five past Swansea City at Etihad Stadium last weekend.
The Hammers conceded four against Arsenal in north London last weekend, with three coming in the last 10 minutes.
It is dabblebet's 21/20 (2.05) quote, then, for the visitors to score more than two goals in this game could well offer punters a path to profit from Sunday's showdown at London Stadium.