The Hornets have beaten Brighton, Burnley and Crystal Palace, while Spurs saw off Newcastle United and Fulham before securing a sensational 3-0 win against Manchester United at Old Trafford on Monday night.
Mauricio Pochettino's men come into this clash as SportPesa's 20/33 (1.61) favourites to take all three points, while the same firm go 9/2 (5.50) that Javi Gracia's charges maintain their 100 per cent record with a win.
SportPesa go 3/1 (4.0) that these two teams preserve their unbeaten record in the competition by playing out a draw.
Son Heung-Min remains unavailable for Spurs, but with three goals in his last two matches, Lucas Moura looks to be a ready-made replacement for the South Korean star.
Roberto Pereyra is a man in form, having already scored three goals in two matches at Vicarage Road this term and Spurs will be wary of the threat posed by the Argentine midfielder.
The north Londoners have been the dominant force in this fixture down the years, having avoided defeat in each of their last 14 fixtures against the Hornets.
That second selection that would have landed in each of Tottenham's last three wins against Watford.
With both sides in fantastic form, however, better value could lie in SportPesa's 31/20 (2.55) quote for more than one goal to be scored before the break at Vicarage Road on Sunday.