Pressure will mount on Mauricio Pochettino's side knowing that Champions League football will be secured should they win their last two remaining games.
Newcastle sit comfortably in 10th place though are on a poor run of form, having lost their last three matches. Rafael Benitez's side face a tough end-of-season run-in having to play both Spurs and Chelsea.
Earlier in the season, Pochettino's men registered a 2-0 win over the Magpies in a heated encounter at St James' Park that involved Jonjoy Shelvey being sent off early in the second half.
|Game||Tottenham vs Newcastle|
|Date||Wednesday, May 9|
|Time||8:00pm BST / 3:00pm ET|
|Stream (US only)||N/A|
TV Channel, Live Stream & How To Watch
In the United States (US), you can watch this match on NBC Sports Gold.
|US TV channel||Online stream|
|NBC Sports Gold||N/A|
In the United Kingdom (UK), the game will not be shown on Sky Sports on BT Sport, however you can follow the match live on Goal .
|UK TV channel||Online stream|
Squads & Team News
|Position||Tottenham Hotspur players|
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Rose, Alderweireld, Sanchez, Dier, Trippier, Aurier, Davies|
|Midfielders||Lamela, Wanyama, Sissoko, Dembele, Alli, Moura, Eriksen|
|Forwards||Kane, Son, Llorente|
Jan Vertonghen will be available for selection despite limping off at West Brom on Saturday, though Harry Winks is out of action for the rest of the season with a long-term ankle injury.
Potential Tottenham starting XI: Lloris; Alderweireld, Sanchez, Vertonghen; Trippier, Wanyama, Eriksen, Davies; Alli, Son; Kane.
|Position||Newcastle United players|
|Goalkeepers||Dubravka, Elliot, Darlow|
|Defenders||Dummett, Lascelles, Hayden, Mbemba, Haidara, Yedlin, Gamez, Manquillo, Lejeune|
|Midfielders||Ritchie, Shelvey, Diame, Kenedy, Merino, Atsu, Murphy|
|Forwards||Gayle, Perez, Joselu|
Islam Slimani is suspended for Newcastle and Ciaran Clark is a doubt, while Christian Atsu has been out for the season with a knee injury.
Potential Newcastle starting XI: Dubravka; Yedlin, Lascelles, Lejeune, Dummett; Ritchie, Merino, Shelvey, Kenedy; Perez; Joselu.
Betting & Match Odds
Tottenham are priced at 2/11 to beat the Magpies, with a draw going for 11/2 and a Newcastle win available at 14/1.
Spurs will be buoyed by their home advantage and Harry Kane eyeing the chance to equal sixth-placed George Hunt (138 goals) in Tottenham's all-time leading scorers list.
Having failed to lift silverware this season – coming up short in the FA Cup, Carabao Cup and Europe – anything less than qualifying for the Champions League next season would be seen as a disappointment for Pochettino and his side.
Sunday's loss against West Brom was the first time that Spurs have failed to score for the first time in 24 matches, though will be comforted knowing that Newcastle registering just one win in their last eight away fixtures.
Benitez will be seeking to end his season on a positive note after losing their last three matches on the bounce, and he could do just that with a result taken from either Spurs or Chelsea.
Pochettino is aware of the weight of Champions League football on his shoulders, admitting that they have their own fate in their hands.
"It looked like after Chelsea the job was done and that's why I'm disappointed in our performances in the last few weeks," the Argentine boss stated .
"We need to work so hard during the last two games to try to win them both because it's in our hands to be in the Champions League next season."