Spurs suffered heavily at the hands of Pep Guardiola's side last season, losing 4-1 at the Etihad and 3-1 at home, so they will be eager to avoid a similar fate in 2018-19.
However, it is sure to be a difficult task, with City coming into the match on the back of a seven-game unbeaten run, with eight goals scored in their last two games alone.
Mauricio Pochettino's side currently find themselves outside the top four in fifth place - albeit thanks to goal difference - but a win would see them leapfrog the champions.
|Game||Tottenham vs Manchester City|
|Date||Monday, October 29|
|Time||8pm GMT / 4pm ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|UNIVERSO / NBC Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League or Sky Sports Main event and it can be streamed online Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League / Sky Sports Main Event||Sky Go|
Squads & Team News
|Goalkeepers||Lloris, Vorm, Gazzaniga, Whiteman|
|Defenders||Trippier, Alderweireld, Vertonghen, Rose, Sanchez, Walker-Peters, Foyth, Aurier, Davies|
|Midfielders||Winks, Lamela, Dier, Sissoko, Wanyama, N'Koudou, Dembele, Alli, Eriksen, Moura, Amos, Skipp|
|Forwards||Kane, Llorente, Janssen, Son|
Tottenham XI: Lloris (C), Trippier, Alderweireld, Sanchez, Davies, Dier, Dembele, Sissoko, Lamela, Lucas, Kane.
Subs: Gazzaniga, Aurier, Walker-Peters, Winks, Eriksen, Dele, Son
|Position||Man City squad|
|Goalkeepers||Bravo, Ederson, Grimshaw, Muric|
|Defenders||Walker, Danilo, Stones, Laporte, Kompany, Mangala, Otamendi, Mendy, Sandler|
|Midfielders||Gundogan, De Bruyne, D. Silva, B. Silva, Delph, Fernandinho, Mahrez, Zinchenko, Foden, Bernabe, Sterling, Sane|
|Forwards||Aguero, Jesus, Diaz|
Potential Man City XI: Ederson, Walker, Stones, Laporte, Mendy, Fernandinho, Silva (C), Mahrez, Bernardo, Sterling, Aguero
Subs: Muric, Kompany, De Bruyne, Sané, Otamendi, Jesus, Foden
Betting & Match Odds
Visitors Man City are favourites to win the game according to bet365, who price Guardiola's side at 3/4. Spurs are 15/4 to win at home and a draw is available at 31/10.
Concerns over the suitability of the Wembley pitch have been dismissed by Guardiola in the lead up to the game and the Catalan is more concerned about handling the Spurs players.
Jacksonville Jaguars played the Philadelphia Eagles at the venue on Sunday, just a day before the Spurs-City showdown, leaving little time for ground staff to prepare the playing surface.
"I think the Premier League doesn't like it too much but it is what it is," Guardiola said. "Hopefully Tottenham can finish a stadium as quickly as possible but it is not necessary to complain about that.
"We have to adapt quickly, figure out that the pitch will not be in perfect conditions and adapt."
City claimed a 7-2 advantage over Spurs over their two league meetings last season, beating them 4-1 at home before recording a 3-1 win at Wembley, but Guardiola is taking nothing for granted.
"They were my first defeat here and I realised how strong they are," stressed the Catalan. "Last season we did really well in both games, but they've got a good manager and good players."
Pochettino, meanwhile, is fully aware of his side's status as underdogs coming into the game against the reigning champions, but he believes they have what it takes to upset their rivals.
"I think we are on a different level - but that doesn't mean we cannot beat them in one game," said the Argentine.